File storage of interface overlap for the subunit ARC40.

In this 8×8 matrix, each row/column represent an interface for binding of ARC40 to each of its 8 partners. Overlapping and non-overlapping interfaces are indicated by 1 and 0, respectively. Diagonal entries are ignored. In the case of self-binding the interaction could be mediated by the same surface on both protein copies (1 matrix entry) or by two distinct surfaces (2 entries). The shared surface of ARC40 is the region that binds to the acidic domains of LAS17, MYO5, MYO3, PAN1, and CRN1. This surface is not specifically known, but the homology of the partners suggests they all bind to the same place. Actin is included as binding to this shared surface because its binding is impeded by binding of LAS17 to ARC40 and there is no additional information on the residues involved in the interactions to determine if the interference is direct or allosteric.