CRYSTAL STRUCTURE OF HBV CAPSID Y132A MUTANT IN COMPLEX WITH N-(3-chloro-4-fluorophenyl)-3-phenyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide AT 2.65A RESOLUTION

Protein Data Bank Japan2024-10-16 更新2026-03-21 收录

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CRYSTAL STRUCTURE OF HBV CAPSID Y132A MUTANT IN COMPLEX WITH N-(3-chloro-4-fluorophenyl)-3-phenyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide AT 2.65A RESOLUTION Descriptor: Capsid protein, ISOPROPYL ALCOHOL, N-(3-chloro-4-fluorophenyl)-3-phenyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide Authors: Kuduk, S.D, Stoops, B, Alexander, R, Lam, A.M, Espiritu, C, Vogel, R, Lau, V, Klumpp, K, Flores, O.A, Hartman, G.D, Lukacs, C.M, Abendroth, J. Deposit date: 2020-09-17 Release date: 2021-07-28 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Identification of a new class of HBV capsid assembly modulator. Bioorg.Med.Chem.Lett., 39, 2021

分辨率为2.65埃的乙型肝炎病毒（Hepatitis B Virus，HBV）衣壳Y132A突变体与N-(3-氯-4-氟苯基)-3-苯基-1,4,6,7-四氢-5H-吡唑并[4,3-c]吡啶-5-甲酰胺复合物的晶体结构描述项：衣壳蛋白、异丙醇、N-(3-氯-4-氟苯基)-3-苯基-2,4,6,7-四氢-5H-吡唑并[4,3-c]吡啶-5-甲酰胺作者：Kuduk, S.D.、Stoops, B.、Alexander, R.、Lam, A.M.、Espiritu, C.、Vogel, R.、Lau, V.、Klumpp, K.、Flores, O.A.、Hartman, G.D.、Lukacs, C.M.、Abendroth, J. 提交日期：2020-09-17 发布日期：2021-07-28 最后修改日期：2024-10-16 实验方法：X射线衍射（2.65埃）引用：《新型HBV衣壳组装调节剂的鉴定》，《生物有机与药物化学快报》（Bioorg.Med.Chem.Lett.），39卷，2021年

创建时间：

2020-09-17