Predictions for how the excitability of L5PCs in response to glutamatergic inputs at proximal and distal apical dendrites is changed by modulation of Ih channels.

Higher excitability (decreased AP threshold) is denoted by ↑, and lower excitability (increased AP threshold) is denoted by ↓. The combinations ↑↑ and ↓↓ represent cases where the combination of cAMP-inhibiting and cAMP-enhancing modulations at different parts of the dendrite caused stronger increase or decrease to the L5PC excitability than any of the two neuromodulations alone.