Association between benzodiazepine prescribing in the first trimester of pregnancy and the risk of major congenital anomalies in offspringa.

aChildren born to women without depression or anxiety as the comparison group & gaps in the table indicated insufficient data available for the specific comparisons.bDoes not include children born to women with co-prescriptions of antidepressants in the first trimester of pregnancy.AOR = odds ratio adjusted for maternal age at childbirth, calendar year at birth at a categorical variables, maternal smoking, body mass index and socioeconomic status.MCAs = major congenital anomalies; CI = confidence interval.