Supplementary Material: Evaluating the quality of the economic evidence in colorectal cancer genomics studies

Supplementary Material:  Evaluating the quality of the economic evidence in colorectal cancer genomics studies
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Table S1. Database Search Strategy  
Table S2. Scope of review and PICO framework
Table S3. Quality of Health Economic Studies (QHES) Scores by Study 
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Background: The increase in the use of genome-based screening and diagnostic tests adds to the overall costs of oncologic care for colorectal cancer. This, in turn, has resulted in an increase in published economic analyses. 
Objectives: To (a) perform a systematic literature review of the available economic evidence evaluating the value of genomic testing for colorectal cancer (b) appraise the quality of the economic studies conducted to date.
Methods: A systematic review of the literature for economic studies of colorectal cancer genomics from January 2006 through October 2020, and evaluation of study quality using the Quality of Health Economic Studies (QHES) instrument was conducted. The validated QHES was then applied to a final set of articles that met eligibility criteria. 
Results: Our search of the literature initially yielded 12,859 records. A final set of 49 articles met our inclusion criteria. The QHES score ranged from 24 to 100, with an average score of 82. Most of the studies (n=40, 82%) scored above 75 and were considered of good quality. 
Conclusion: Our analysis revealed that most of the economic analyses of colorectal cancer genomic molecular diagnostics in the literature may be of good quality. There is, however, some variation in methodological rigor between the articles
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