Data extraction table for "Health effects of drinking 100% fruit and/or vegetable juice: An umbrella review of systematic reviews and meta-analyses"

The full data extraction table for "Health effects of drinking 100% fruit and/or vegetable juice: An umbrella review of systematic reviews and meta-analyses" - registered as "What are the effects of 100% fruit and/or vegetable juice consumption, as compared to placebo or low intakes, on human health outcomes relevant to population health?" PROSPERO 2022 CRD42022380588 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022380588 We conducted an umbrella review of systematic literature reviews (SLRs) with meta-analyses (MAs) to summarise the health benefits of drinking 100% fruit and/or vegetable juice. Four electronic databases will be searched from inception with no date limits: MEDLINE (via PubMed), The Cochrane Library (Reviews and CENTRAL), EMBASE, and CINAHL (via EBSCO). The systematic search strategy was designed to include a combination of both controlled vocabulary (MeSH terms and publication type) and keywords (by title and abstract). The keywords repeated the controlled vocabulary terms plus keywords specific to the topic. The search strategy was designed in PubMed and then translated to the other databases. Types of study to be included Systematic literature reviews with meta-analysis.Exclusions: Systematic literature reviews with no meta-analysis, cross-sectional studies, single arm interventions, narrative reviews, expert opinion articles, or consensus guidelines. Screening, quality, risk of bias and content overlap tools were applied, and extracted data are tabulated (tab 1), GRADE applied (tab 2) and ROBIS applied (tab 3). Data represent almost 2 million subject data points. Of the primary MAs 10 MAs reported health benefits (blood pressure, vascular function, inflammation, stroke mortality), three MAs reported adverse risks (CVD mortality, prostate cancer, type 2 diabetes risk), while most reported no effect (blood lipids, body composition, liver function, metabolic health, cancers, and inflammation). Findings confirm there are health benefits associated with 100% juice consumption, with limited harms identified at this level of evidence. The balance of evidence continues to support the inclusion of 100% juice as a core food in dietary guidelines.

本研究针对“饮用100%纯果蔬汁的健康效应：一项针对系统综述与荟萃分析的伞状综述”开展全量数据提取表整理，该研究的预设注册问题为：“与安慰剂组或低摄入量组相比，100%纯果蔬汁的摄入对与人群健康相关的人类健康结局有何影响？”，注册于PROSPERO数据库（编号CRD4202238058），可通过以下链接获取注册详情：https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202238058。

本研究针对纳入荟萃分析（meta-analysis, MA）的系统综述（systematic literature review, SLR）开展了伞状综述，旨在总结饮用100%纯果蔬汁的健康获益。我们已从各数据库建库起始、无时间限制地检索4个电子学术数据库：MEDLINE（通过PubMed平台检索）、Cochrane图书馆（包含综述库与CENTRAL对照试验注册库）、EMBASE以及CINAHL（通过EBSCO平台检索）。

系统检索策略结合了受控词汇（医学主题词MeSH术语及出版类型字段）与关键词（基于标题和摘要检索），关键词在受控词汇的基础上补充了本研究主题的专属词汇。检索策略首先在PubMed平台构建，随后适配至其余三个数据库。

纳入研究类型为含荟萃分析的系统综述；排除无荟萃分析的系统综述、横断面研究、单臂干预研究、叙述性综述、专家意见类文章及共识指南。

本研究采用筛选工具、质量评价工具、偏倚风险评估工具及内容重叠分析工具对文献进行处理，提取的数据已整理为表格（表1），并分别采用GRADE分级法（表2）与ROBIS偏倚风险评估工具（表3）进行分析。本次研究整合的受试者数据总量近200万条。

在纳入的原始荟萃分析中，10项荟萃分析报告了100%纯果蔬汁摄入的健康获益（涉及血压、血管功能、炎症反应、卒中死亡率），3项荟萃分析报告了不良健康风险（包括心血管疾病死亡率、前列腺癌发病风险、2型糖尿病发病风险），其余多数荟萃分析未观察到显著效应（涉及血脂水平、身体成分、肝功能、代谢健康、各类癌症及炎症反应）。

本研究结果证实，100%纯果蔬汁摄入与明确的健康获益相关，现有证据层面仅识别出有限的不良风险。当前证据仍支持将100%纯果蔬汁纳入膳食指南的核心食物范畴。