CoRSIV mQTL full output results

Access the following article here: https://rdcu.be/c3SCx Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control Genome Biology Genetic variants can modulate phenotypic outcomes via epigenetic intermediates, for example at methylation quantitative trait loci (mQTL). We present the first large-scale assessment of mQTL at human genomic regions selected for interindividual variation in CpG methylation, which we call correlated regions of systemic interindividual variation (CoRSIVs). These can be assayed in blood DNA and do not reflect interindividual variation in cellular composition.访问以下文章：https://rdcu.be/c3SCx。该文章标题为《人类全身性个体间表观遗传变异与转座因子相关且受强烈遗传调控》，发表于《基因组生物学》（Genome Biology）期刊。遗传变异可通过表观遗传中介物调控表型结果，例如在甲基化数量性状位点（methylation quantitative trait loci, mQTL）处。本研究首次针对因CpG甲基化个体间差异而筛选得到的人类基因组区域开展大规模mQTL分析，我们将这类区域命名为全身性个体间变异相关区域（correlated regions of systemic interindividual variation, CoRSIVs）。这类区域可通过血液DNA进行检测，且不会反映细胞组成的个体间差异。