FluoroFusion: NHC-Catalyzed Nucleophilic Aromatic Substitution Reaction Unveils Functional Perfluorinated Diarylmethanones

A mild, facile, and metal-free approach via the N-heterocyclic carbene-catalyzed SNAr reaction between aryl aldehydes with perfluoroarenes to obtain the coveted functional perfluorinated diarylmethanones is disclosed. This method accommodates a diverse substrate range and exhibits notable tolerance toward various functional groups. Our success in modifying biologically relevant molecules, crafting a fully fluorinated bioisosteric analogue of drug candidate D1, and highlighting the potential of these ketones as valuable electrolyte additives for lithium-ion batteries (LIBs) underscores the versatility of our methodology.本研究公开了一种温和、简便且无金属的合成方法，该方法通过氮杂环卡宾（N-heterocyclic carbene）催化芳醛与全氟芳烃之间的亲核芳香取代（SNAr）反应，以制备目标功能化全氟二芳基甲酮。该方法底物适用范围广泛，对多种官能团均表现出优异的耐受性。我们成功对生物活性相关分子进行修饰，制备了候选药物D1的全氟代生物电子等排体类似物，并证实了这类酮类化合物可作为锂离子电池（LIBs）中极具应用价值的电解质添加剂，上述成果充分凸显了本合成方法的通用性。