Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex.

Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, Ecto-NAD+ glycohydrolase (CD38 molecule), ... Authors: Egea, P.F, Muller-Steffner, H, Stroud, R.M, Kellenberger, E, Oppenheimer, N, Schuber, F. Deposit date: 2009-03-02 Release date: 2010-03-16 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. Plos One, 7, 2012CD38催化机制的结构解析：构象柔性共价酶-底物复合物的证据。描述项：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、二甲胂酸根离子、胞外NAD+糖水解酶（CD38分子）等。作者：Egea P.F.、Müller-Steffner H、Stroud R.M.、Kellenberger E、Oppenheimer N、Schuber F. 提交日期：2009-03-02，发布日期：2010-03-16，最后修改日期：2024-11-20。实验方法：X射线衍射（分辨率1.8埃）。引用文献：《牛CD38/NAD+糖水解酶的米氏复合物及共价捕获中间体的X射线结构解析其作用机制》，《公共科学图书馆·综合》，第7卷，2012年