Spatial Transcriptomics Identifies Immune-Stromal Niches Associated with Cancer in Adult Dermatomyositis

This dataset contains two primary R data objects from our study on adult-onset dermatomyositis (DM) and cutaneous lupus erythematosus (CLE): 5k_paper.RDS: Spatial Seurat object containing high-resolution spatial transcriptomics data (Xenium Prime 5K, 10X Genomics) from 17 skin biopsies including: 12 DM lesional samples 2 CLE lesional samples 3 healthy control samples main_obj_48samples.RDS: Seurat object containing single-cell RNA sequencing data (Chromium Single Cell Gene Expression Flex) from 44 skin biopsies including: 22 DM patients (lesional) 9 CLE patients (lesional) 8 non-lesional samples from a subset of patients 6 healthy controls本数据集包含本研究针对成人发作性皮肌炎（dermatomyositis, DM）与皮肤红斑狼疮（cutaneous lupus erythematosus, CLE）所开展的研究中的两类核心R数据对象： 5k_paper.RDS：空间Seurat对象，包含来自17份皮肤活检样本的高分辨率空间转录组学数据（Xenium Prime 5K，10X Genomics），具体包括： 12份DM皮损样本 2份CLE皮损样本 3份健康对照样本 main_obj_48samples.RDS：Seurat对象，包含来自44份皮肤活检样本的单细胞RNA测序数据（Chromium Single Cell Gene Expression Flex），具体包括： 22例DM患者皮损样本 9例CLE患者皮损样本 8份来自部分患者的非皮损样本 6份健康对照样本