Biochemical response to metformin.

Values are shown at Visit 1 and Visit 2 for all participants and stratified by those participants who took no or any number of (1, 2, 3, or 4) metformin pills. a The mean ± SD for glucose and median [interquartile range] for non-normally distributed measures (insulin, HOMA-IR, glucagon, and proinsulin) are shown at Visit 1 and Visit 2. For statistical comparison, non-normally distributed data were log-transformed and paired difference for log-transformed measures is the mean of the log-transformed value at Visit 2 minus log-transformed value at Visit 1. bP-value is for paired t-test for glucose and for log-transformed insulin, HOMA-IR, glucagon, and proinsulin. SD: standard deviation. CI: confidence interval. HOMA-IR: homeostatic model assessment of insulin resistance. Biochemical response to metformin.