Acute Lyme Disease patient subsets defined by circulating mediators versus clinical phenotypes.

Table 2 shows group differences based on the heat map generated using SAM (see Figure 1). No demographic differences between groups were seen. Categorical variables were compared using Fisher's Exact tests, while continuous variables were compared using unpaired t-tests. Lymphocyte values given are mean (standard deviation), while other values given are a percentage of the respective subset. Number of symptoms pre-treatment is defined as the number of symptoms reported by the patient during structured interview by the principle investigator (JNA) or study staff (LAC). Illness duration is defined as the period of time between first sign or symptom of disease and presentation for treatment and enrollment in the study.aAcute Lyme Mediator High n = 26; Acute Lyme Mediator Low n = 17;bAcute Lyme Mediator High n = 27; Acute Lyme Mediator Low n = 15.