Acute Lyme Disease patient subsets defined by circulating mediators versus clinical phenotypes.

Table 2 shows group differences based on the heat map generated using SAM (see Figure 1). No demographic differences between groups were seen. Categorical variables were compared using Fisher's Exact tests, while continuous variables were compared using unpaired t-tests. Lymphocyte values given are mean (standard deviation), while other values given are a percentage of the respective subset. Number of symptoms pre-treatment is defined as the number of symptoms reported by the patient during structured interview by the principle investigator (JNA) or study staff (LAC). Illness duration is defined as the period of time between first sign or symptom of disease and presentation for treatment and enrollment in the study.aAcute Lyme Mediator High n = 26; Acute Lyme Mediator Low n = 17;bAcute Lyme Mediator High n = 27; Acute Lyme Mediator Low n = 15.表2展示了基于使用SAM（Segment Anything Model）生成的热图所得到的组间差异（详见图1）。各组间未观察到人口统计学差异。分类变量采用费希尔精确检验（Fisher's Exact tests）进行比较，连续变量则采用独立样本t检验（unpaired t-tests）进行比较。所给出的淋巴细胞数值为平均值（标准差），其余数值均为对应亚群的占比。治疗前症状计数定义为患者在首席研究员（JNA）或研究人员（LAC）开展的结构化访谈中报告的症状总数。病程定义为从疾病首次出现体征或症状，至患者就诊并纳入本研究的时间间隔。a 高急性莱姆病介质组n=26；低急性莱姆病介质组n=17；b 高急性莱姆病介质组n=27；低急性莱姆病介质组n=15。