Table_1_Characteristics and Prognostic Analysis of 55 Patients With Pulmonary Sarcomatoid Carcinoma.doc

Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non-small-cell lung cancer (NSCLC). Here, we present information on the clinicopathologic characteristics and clinical outcomes of this type of cancer. Clinicopathologic data from 55 patients treated at a single cancer center from January 2011 to December 2018 were retrospectively analyzed. The patients were mostly male (76.4%), with a median age of 66 years and a history of smoking (54.5%). Most had symptoms, and about 60% presented with locally advanced or metastatic disease at diagnosis. Of the 55 cases, 21 were diagnosed by surgical resection. Pleomorphic cancer was the most common subtype (58.1%). With a median follow-up period of 13.2 months, the average survival time of the patients was 16.1 months, and the median survival time was 12 months. The overall survival rates for 1, 2, and 3 years were 52.7%, 18.2%, and 9.1%, respectively. Univariate analysis showed that prognosis of the patients was influenced by tumor size, T stage, metastatic status, and surgery (p < 0.05). Multivariate analysis showed that T stage (p = 0.034) was an independent prognostic factor. There are few reports on the natural history of PSC, and its clinicopathological characteristics remain unclear. Herein, a retrospective review 55 individuals with PSC found that T stage was an independent predictor of survival. Surgical resection was associated with better prognosis.

肺肉瘤样癌（PSC）是一种罕见且侵袭性强的非小细胞肺癌（NSCLC）亚型。本研究旨在阐述该类型癌症的病理学特征及临床预后。对2011年1月至2018年12月期间于单一癌症中心接受治疗的55例患者的临床病理数据进行了回顾性分析。患者中男性占多数（76.4%），中位年龄为66岁，且有吸烟史（54.5%）。大多数患者有症状，约60%在诊断时表现为局部晚期或转移性疾病。在55例病例中，有21例通过手术切除确诊。多形性癌是最常见的亚型（58.1%）。中位随访期为13.2个月，患者的平均生存时间为16.1个月，中位生存时间为12个月。1年、2年和3年的总生存率分别为52.7%、18.2%和9.1%。单因素分析显示，患者的预后受肿瘤大小、T分期、转移状态及手术等因素的影响（p < 0.05）。多因素分析表明，T分期（p = 0.034）是独立的预后因素。关于PSC的自然史报道较少，其临床病理学特征尚不明确。本研究对55例PSC患者进行了回顾性分析，发现T分期是生存的独立预测因子。手术切除与更好的预后相关。