Additional file 1: of Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity

Figure S1. Comparison of serum cytokines between AOSD and HC. Serum IL-1β (a), IL-1Rα (b), TNF-α (c), soluble tumor necrosis factor receptor (d), IL-6 (e), IL-18 (f), IL-17 (g), and IL-10 (h) protein levels among patients with AOSD with active and inactive disease activity (active [n = 41] versus inactive [n = 21]) as well as HC (n = 50) were determined by ELISA. Each symbol represents an individual patient with AOSD and an HC. Horizontal lines indicate median values. The data represent the mean ± SD. *** P < 0.001 by Student’s t test. Figure S2. Comparison of serum IL-37 levels between patients with AOSD with different disease patterns. (a) The serum IL-37 levels in 59 patients with AOSD with a systemic course and 3 with an articular course. (b) The serum IL-37 levels in 39 patients with AOSD with a monophasic course, 20 with a polycyclic course and 3 with an articular course. Data are expressed as the mean ± SD. The Mann-Whitney U test was used to perform the statistical analysis. (ZIP 2677 kb)

图S1. 成人斯蒂尔病（AOSD）与健康对照（HC）的血清细胞因子比较。本研究采用酶联免疫吸附试验（ELISA）检测了疾病活动期（活动期[n=41] vs 非活动期[n=21]）的AOSD患者以及健康对照（n=50）的血清IL-1β(a)、IL-1Rα(b)、TNF-α(c)、可溶性肿瘤坏死因子受体(d)、IL-6(e)、IL-18(f)、IL-17(g)及IL-10(h)的蛋白水平。每个符号代表1名AOSD患者或健康对照，横线表示中位数，数据以平均值±标准差（SD）呈现，经Student’s t检验，*** P < 0.001。图S2. 不同疾病表型的AOSD患者血清IL-37水平比较。(a) 59例全身型病程AOSD患者与3例关节型病程AOSD患者的血清IL-37水平；(b) 39例单相型病程、20例多循环型病程及3例关节型病程AOSD患者的血清IL-37水平。数据以平均值±标准差表示，采用曼-惠特尼U检验（Mann-Whitney U test）进行统计分析。(ZIP 2677 kb)