Single cell RNA sequencing profile of progeny of a unique mesenchymal progenitor subset traced to adult mouse skeletal muscle

During mouse embryonic development, as the limb bud expands, several populations of cells are thought to migrate into the emerging limb and contribute to various specialized structures therein. A unique subset has been identified among the migrating populations that contributes to enduring stromal compartments in various tissues. Using a lineage tracing tool, this population was sampled from limb muscle after post-natal development was complete and gene expression was profiled at the single cell level to determine the fate and function of this cell subtype and the genetic programs involved. Single cell RNA-seq analyes of mesenchymal progenitors labelled in the developing murine embryo and traced through post natal development.