首页/数据集/Kinase activity of RIOK2 transports complex from lysosome to ER and triggers spatial cleavage of GSDMD

Kinase activity of RIOK2 transports complex from lysosome to ER and triggers spatial cleavage of GSDMD

NIAID Data Ecosystem2026-05-02 收录

细胞焦亡机制

激酶信号转导

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https://www.ncbi.nlm.nih.gov/sra/SRP601087 数据链接链接失效反馈

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RNA sequence analysis revealed no significant different of Il1b, Tlr4, Tnfr, Fadd, Ripk1, caspase-8, Gsdmd mRNA level in Riok2 deficient iBMDM or BMDMs (

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创建时间：

2025-07-16

类器官免疫模型

细胞焦亡机制

Immune cells play critical roles in causing host damage in various diseases, including infectious diseases. However, there is a paucity of human models to study immune-mediated host damage. Here, we s

NIAID Data Ecosystem40

DataSheet8_Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis.ZIP

糖尿病肾病治疗

细胞焦亡机制

Background: Fucoidan (FPS) has been widely used to treat renal fibrosis (RF) in patients with diabetic kidney disease (DKD); however, the precise therapeutic mechanisms remain unclear. Recently, resea

NIAID Data Ecosystem30

Chronic intermittent hypoxia induces the pyroptosis of renal tubular epithelial cells by activating the NLRP3 inflammasome

肾病病理学

细胞焦亡机制

Obstructive sleep apnea syndrome (OSAS) is a respiratory disorder and chronic intermittent hypoxia (CIH) is an important pathological characteristic of OSAS. Injuries on renal tubular epithelial cells

NIAID Data Ecosystem30

Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA

蛋白质晶体学

激酶信号转导

Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA Descriptor: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, cAMP-dependent protein kina

Protein Data Bank Japan2024-10-30 更新40

Innate immune sensing of influenza virus through IFI16 promote pyroptosis.

抗病毒先天免疫

细胞焦亡机制

We report that IFI16, which was previously identified as a cytosolic DNA sensor, is essential for the activation of programmed cell death pathways in IAV infected cells. We have identified IFI16 as an

NIAID Data Ecosystem30

Kinase activity of RIOK2 transports complex from lysosome to ER and triggers spatial cleavage of GSDMD

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