Asymmetric Total Synthesis of the Highly Strained 4β-Acetoxyprobotryane-9β,15α-diol
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https://figshare.com/articles/dataset/Asymmetric_Total_Synthesis_of_the_Highly_Strained_4_-Acetoxyprobotryane-9_15_-diol/13221773
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资源简介：
The first and asymmetric total synthesis
of 4β-acetoxyprobotryane-9β,15α-diol,
containing a rare and highly strained trans-fused
bicyclo[3.3.0]octane ring system, has been achieved. The synthetically
challenging [6–5–5] tricyclic ring system in the final
product was efficiently and diastereoselectively synthesized via an
asymmetric rhodium-catalyzed [4 + 2] cycloaddition reaction, followed
by a unique benzilic acid type rearrangement under very mild conditions.
The seven contiguous stereocenters were installed efficiently and
diastereoselectively.
创建时间：
2020-11-11
