Data from: Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit

The computational capabilities of neuronal networks are fundamentally
constrained by their specific connectivity. Previous studies of cortical
connectivity have been mostly carried out in rodents; however, whether the
principles also apply to the evolutionary expanded human cortex is
unclear. Here we studied network properties within the human temporal
cortex using samples obtained from brain surgery. We analyzed multi-neuron
patch-clamp recordings in layer 2-3 pyramidal neurons and identified
substantial differences compared to rodents. Reciprocity showed random
distribution, synaptic strength was independent from connection
probability and connectivity of the supragranular temporal cortex followed
a directed and mostly acyclic graph topology. Application of these
principles in neuronal models increased the dimensionality of network
dynamics suggesting a critical role for cortical computation.