five

In vivo characterization of Linc-p21 reveals functional cis-regulatory DNA elements

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE73472
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We have sequenced wildtype and mutant heart, liver, lung, and hindlimb from E14.5 embryos of the mutant lncRNA strain Trp53cor1tm1.1Vlcg (lincp21), and performed a massively parallel reporter assay (MPRA) in mouse myoblast cells (C2C12). Comparison between wildtype and mutant organ transcriptomes in the Trp53cor1tm1.1Vlcg strain. Additionally, we include a comparison between MPRA signal vector tag distributions and C2C12 tag distributions.
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2019-05-15
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