Vitamin D supplementation and cardiac inflammation (Vitamina D; PI: M Turiel)

Raw data of the clinical trial NCT03403933. We enrolled older adults scheduled for major orthopaedic surgery and suffering from hypovitaminosis D. Patients underwent 6-months calcifediol supplementation after surgery. After the normalization of low levels of vitamin D, we were able to observe a reduction of circulating TNFα and ADMA together with the amelioration of cardiac function. The dataset was used to write the article "Vitamin D, cardio-inflammation, and endothelial dysfunction in older adults after orthopedic surgery: results from an open-label trial to ameliorate cardiac function", which was published by the Journal of Nutrition clinique et métabolisme in 2020.

本数据集为临床试验NCT03403933的原始数据。本研究招募了拟接受大型骨科手术且合并维生素D缺乏（hypovitaminosis D）的老年受试者，所有受试者在术后接受为期6个月的骨化二醇（calcifediol）补充治疗。待受试者的低维生素D水平恢复至正常范围后，本研究团队观察到循环肿瘤坏死因子α（TNF-α）与不对称二甲基精氨酸（ADMA）的循环水平均有所降低，同时心功能得到改善。本数据集被用于撰写论文"骨科术后老年人群的维生素D、心脏炎症与内皮功能障碍：一项改善心功能的开放标签试验结果"，该论文于2020年发表于《临床与代谢营养杂志》（Journal of Nutrition clinique et métabolisme）。