Specificity of compound 6 on different K⁺ channel subtypes.

The specificity of compound 6 at 25 µM and 50 µM towards various Kv channels was tested in Xenopus oocytes, except for Kv1.2 which was checked in transfected CHO cells. The current amplitude of the various Kv channels was tested at the indicated voltages and the effect of the drugs was expressed as fold of the control amplitude measured under the same conditions in the absence of the drug. Data are expressed as mean±SEM of 5-7 separate experiments. * significance p<0.01.