The deregulated microRNAome contributes to the cellular response to aneuploidy [miRNA]

Aneuploidy severely alters cell physiology and is widespread in cancers and other pathologies. In model cell lines, aneuploidy impairs proliferation, leads to proteotoxic as well as replication stress and triggers conserved transcriptome and proteome changes. In this study we analysed for the first time miRNAs and demonstrate that their expression is altered in response to chromosome gain. Overall design: HiSeq Illumina sequencing of total RNA including small RNAs for seven whole-chromosome aneuploid cell lines and their corresponding parental cell line.