Minimal critical region (MCR) in choriocarcinomas.

(1)The localization of MCRs with a contribution of de novo choriocarcinomas are indicated in bold.(2)BeWo = A, JAR = B, JEG = C.(3)The genes that meet the selection criteria and were selected are indicated in bold characters. The genes subject to parental imprinting are underlined : (m) = maternal imprinted gene; (p) = paternal imprinted gene. The genes that does not meet the selection criteria but are of interest for various reasons are indicated in plain characters.(4)BeWo and JEG are included for simplicity although they don't define a real MCR.(5)indicate the “wave-crest” amplification of the JAR cell line probably the site of chromothripsis phenomenon [45]. A basal gain under it was observed between 12pter and 12q21.3.(6)JAR contribute for only mir 371 372 & 373.(1) 携带有新发绒毛膜癌贡献特征的MCRs（Minimal Common Regions，最小共同区域）的定位以粗体标注。 (2) BeWo对应A，JAR对应B，JEG对应C。 (3) 符合筛选标准并被纳入分析的基因以粗体标注；受亲本印记调控的基因以下划线标注：其中(m)代表母系印记基因，(p)代表父系印记基因。不符合筛选标准但出于多种研究目的仍具研究价值的基因则以常规字体标注。 (4) 尽管BeWo与JEG并不构成真正的MCR，但为简化分析仍将其纳入。 (5) 本数据集标注了JAR细胞系的“波峰状”扩增区域，该区域大概率为染色体碎裂（chromothripsis）现象的发生位点[45]。在该区域下方，12pter（12号染色体短臂末端）至12q21.3（12号染色体长臂2区1带3亚区）区间存在基础拷贝数增加现象。 (6) JAR细胞系仅涉及miR-371、miR-372及miR-373。