Site-Specific Preparation of 3-Fluoro-1-substituted-naphthalenes via a Novel Base-Catalyzed Cyclization Reaction from (<i>E</i>)-Monofluoroenynes<sup>§</sup>
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资源简介：
A novel cyclization reaction for the preparation of 3-fluoro-1-substituted-naphthalenes is reported. (E)-Monofluoroenynes, which are prepared by Sonogashira coupling reaction from (Z)-1-bromo-1-fluoroalkenes, undergo cyclization to afford 3-fluoro-1-substituted-naphthalenes in good to excellent yields when treated with DABCO or DBU in refluxing N-methyl-2-pyrrolidinone (NMP).
创建时间：
2016-03-01
