Palladium-Catalyzed Cascade Reactions of Isocyanides with Enaminones: Synthesis of 4‑Aminoquinoline Derivatives

A method for palladium-catalyzed cascade reactions of isocyanides with enaminones has been developed. This methodology provides a direct approach to 4-aminoquinoline derivatives under mild conditions with up to 98% yields.本工作开发了一种钯催化（palladium-catalyzed）异氰（isocyanides）与烯胺酮（enaminones）的级联反应（cascade reactions）方法。该合成策略可在温和反应条件下直接制备4-氨基喹啉衍生物（4-aminoquinoline derivatives），最高产率（yields）可达98%。