A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severity ,A study of Zhu et al

Supplementary Tables from the study: one-sample and two-sample Mendelian randomization studies of white blood cell counts (WBC) and low-density lipoprotein cholesterol (LDL-C) on COVID-19 susceptibility and severity with summary statistics obtained from East Asian and European populations, two-sample reverse Mendelian randomization studies with exposure variable as COVID-19 disease and outcome variable as WBC and LDL-C. In details, Table S1. Seven top SNP-trait significant associations and the corresponding one-sample and two-sample MR results with COVID-19 severity obtained from our dataset, related to Figure 4. Table S2. Two-sample MR results with SNP-exposure summary statistics from our dataset and SNP-outcome summary statistics from HGI database, related to Figure 4. Table S3. Two-sample MR results based on one WBC-associated SNP in gene HLA-C from an EAS study and SNP-outcome summary statistics from HGI database, related to Figure 5. Table S4. Summary statistics of a list of WBC-related SNPs in an EAS population and their associations in HGI and the corresponding two-sample MR results, related to Figure 5. Table S5. Two-sample MR results based on one LDL.C-associated SNP in gene ApoE from an EAS study and SNP-outcome summary statistics from HGI database, related to Figure 5. Table S6. Summary statistics of a list of LDL.C-related SNPs in an EAS population and their associations in HGI and the corresponding two-sample MR results, related to Figure 5. Table S7. Two-sample MR results based on one WBC-associated SNP in gene HLA-DPA1/HLA-DPB1 from an EUR study and SNP-outcome summary statistics from HGI database, related to Figure 5. Table S8. Summary statistics of a list of WBC-related SNPs in an EUR population and their associations in HGI and the corresponding two-sample MR results, related to Figure 5. Table S9. Two-sample MR results based on one LDL.C-associated SNP in gene ApoE from an EUR study and SNP-outcome summary statistics from HGI database, related to Figure 5. Table S10. Summary statistics of a list of LDL.C-related SNPs in an EUR population and their associations in HGI and the corresponding two-sample MR results, related to Figure 5. Table S11. Summary statistics of a list of COVID19-related SNPs from the HGI database and their associations with WBC in our dataset and the corresponding two-sample MR results, related to Table 3. Table S12. Summary statistics of a list of COVID19-related SNPs from the HGI database and their associations with LDL-C in our dataset and the corresponding two-sample MR results, related to Table 3. Table S13. Summary statistics of a list of COVID19-related SNPs from the HGI database and their associations with WBC in an UKBB study and the corresponding two-sample MR results, related to Table 3. Table S14. Summary statistics of a list of COVID19-related SNPs from the HGI database and their associations with LDL-C in an UKBB study and the corresponding two-sample MR results, related to Table 3.

本研究的补充表格涵盖两项核心孟德尔随机化（Mendelian randomization, MR）研究相关的汇总统计数据：其一为针对东亚（East Asian, EAS）和欧洲（European, EUR）人群的白细胞计数（white blood cell counts, WBC）与低密度脂蛋白胆固醇（low-density lipoprotein cholesterol, LDL-C）对新冠易感性及重症程度的单样本、双样本MR研究；其二为以新冠疾病为暴露变量、白细胞计数与低密度脂蛋白胆固醇为结局变量的双样本反向MR研究。
具体如下：
表S1：7项顶级SNP（单核苷酸多态性，Single Nucleotide Polymorphism）-表型显著关联结果，以及本数据集来源的与新冠重症相关的单样本、双样本MR分析结果，对应图4。
表S2：基于本数据集的SNP-暴露汇总统计量与HGI数据库的SNP-结局汇总统计量得到的双样本MR分析结果，对应图4。
表S3：基于东亚人群研究中HLA-C基因内1个与白细胞计数相关的SNP，结合HGI数据库的SNP-结局汇总统计量得到的双样本MR分析结果，对应图5。
表S4：东亚人群中一系列与白细胞计数相关的SNP的汇总统计量、它们在HGI数据库中的关联结果，以及对应的双样本MR分析结果，对应图5。
表S5：基于东亚人群研究中ApoE基因内1个与低密度脂蛋白胆固醇相关的SNP，结合HGI数据库的SNP-结局汇总统计量得到的双样本MR分析结果，对应图5。
表S6：东亚人群中一系列与低密度脂蛋白胆固醇相关的SNP的汇总统计量、它们在HGI数据库中的关联结果，以及对应的双样本MR分析结果，对应图5。
表S7：基于欧洲人群研究中HLA-DPA1/HLA-DPB1基因内1个与白细胞计数相关的SNP，结合HGI数据库的SNP-结局汇总统计量得到的双样本MR分析结果，对应图5。
表S8：欧洲人群中一系列与白细胞计数相关的SNP的汇总统计量、它们在HGI数据库中的关联结果，以及对应的双样本MR分析结果，对应图5。
表S9：基于欧洲人群研究中ApoE基因内1个与低密度脂蛋白胆固醇相关的SNP，结合HGI数据库的SNP-结局汇总统计量得到的双样本MR分析结果，对应图5。
表S10：欧洲人群中一系列与低密度脂蛋白胆固醇相关的SNP的汇总统计量、它们在HGI数据库中的关联结果，以及对应的双样本MR分析结果，对应图5。
表S11：从HGI数据库获取的一系列新冠相关SNP的汇总统计量、它们在本数据集中与白细胞计数的关联结果，以及对应的双样本MR分析结果，对应表3。
表S12：从HGI数据库获取的一系列新冠相关SNP的汇总统计量、它们在本数据集中与低密度脂蛋白胆固醇的关联结果，以及对应的双样本MR分析结果，对应表3。
表S13：从HGI数据库获取的一系列新冠相关SNP的汇总统计量、它们在英国生物银行（UK Biobank, UKBB）研究中与白细胞计数的关联结果，以及对应的双样本MR分析结果，对应表3。
表S14：从HGI数据库获取的一系列新冠相关SNP的汇总统计量、它们在英国生物银行研究中与低密度脂蛋白胆固醇的关联结果，以及对应的双样本MR分析结果，对应表3。