Molecular expression in endometrial biopsies of non-viable ectopic and intrauterine pregnancies.

Ectopic pregnancy is the leading cause of morbidity and mortality among women in the first trimester. A reliable diagnostic test for the detection of ectopic pregnancy in cases of non-viable pregnancy of unknown location (NV-PUL) is needed. The objective of the current study is to prospectively validate our previous findings of a 12-cilia gene classifier for the identification of ectopic pregnancy. Molecular interrogation is performed to define differences in molecular expression profiles in ectopic and abnormal intrauterine pregnancies. These samples come from a prospective cohort study comparing transcriptome profiles from women with ectopic pregnancy (ECT) or non-viable intrauterine pregnancy (NV-IUP). Samples were analyzed with the Affymetrix Human Gene 2.0 ST Array. 13 endometrial biopsies taken from women with non-viable intrauterine (n=1) and ectopic (n=12) pregnancies