Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico

The operational impact of deltamethrin resistance on the efficacy of indoor insecticide applications to control Aedes aegypti was evaluated in Merida, Mexico. A randomized controlled trial quantified the efficacy of indoor residual spraying (IRS) against adult Ae. aegypti in houses treated with either deltamethrin (to which local Ae. aegypti expressed a high degree of resistance) or bendiocarb (to which local Ae. aegypti were fully susceptible) as compared to untreated control houses. All adult Ae. aegypti infestation indices during 3 months post-spraying were significantly lower in houses treated with bendiocarb compared to untreated houses (odds ratio <0.75; incidence rate ratio < 0.65) whereas no statistically significant difference was detected between the untreated and the deltamethrin-treated houses. On average, bendiocarb spraying reduced Ae. aegypti abundance by 60% during a 3-month period. Results demonstrate that vector control efficacy can be significantly compromised w...

本研究于墨西哥梅里达地区，评估了溴氰菊酯(deltamethrin)抗药性对室内杀虫剂施用防控埃及伊蚊(Aedes aegypti)实际应用效果的影响。研究采用随机对照试验，对比了经溴氰菊酯（当地埃及伊蚊对其呈现高抗药性）、残杀威(bendiocarb)（当地埃及伊蚊对其完全敏感）处理的住宅，以及未处理的对照住宅，量化了室内滞留喷洒(indoor residual spraying, IRS)对成蚊的防控效果。施药后3个月内的所有埃及伊蚊成蚊侵染指数均显示，经残杀威处理的住宅显著低于未处理住宅（比值比(odds ratio)<0.75；发病密度比(incidence rate ratio)<0.65）；而溴氰菊酯处理住宅与未处理住宅之间未检测到统计学显著差异。平均而言，残杀威喷洒在3个月周期内可使埃及伊蚊种群丰度降低60%。研究结果表明，媒介生物防控效果可显著受损……