GLYCATED HEMOGLOBIN AND FRUCTOSAMINE IN DOGS WITH DIABETES MELLITUS

Abstract Diabetes mellitus (DM) commonly occurs in dogs, and the laboratorial confirmation is carried out by glycemia test. The diagnosis and monitoring in humans is made by glycated hemoglobin and fructosamine concentrations. The objective of this study was to diagnose DM in 19 dogs, by evaluating seric glucose, glycated hemoglobin and fructosamine concentrations. Six dogs with DM and treated with insulin were assisted during a twelve-month period, by means of the same blood analysis, until the death (three dogs) or glycemic control (three dogs). Glucose, glycated hemoglobin and fructosamine increased in all dogs with DM, and dogs that did not survive presented higher glycated hemoglobin and seric glucose values than those that survived at the last evaluation. The results showed the importance of evaluating glycated hemoglobin and fructosamine in dogs with DM to diagnose and control treatment effectiveness.

摘要：糖尿病（Diabetes mellitus, DM）在犬类中较为常见，其实验室确诊需通过血糖检测（glycemia test）完成。针对人类糖尿病的诊断与病情监测，通常采用糖化血红蛋白（glycated hemoglobin）与果糖胺（fructosamine）浓度检测手段。本研究旨在通过检测血清葡萄糖（seric glucose）、糖化血红蛋白及果糖胺浓度，对19只犬的糖尿病进行确诊。6只确诊糖尿病且接受胰岛素治疗的犬接受了为期12个月的随访，期间采用相同的血液分析项目进行检测，直至其死亡（共3只）或实现血糖控制（共3只）。所有糖尿病患犬的葡萄糖、糖化血红蛋白及果糖胺水平均出现升高；在末次评估中，未存活患犬的糖化血红蛋白与血清葡萄糖水平高于存活患犬。本研究结果表明，对糖尿病患犬检测糖化血红蛋白与果糖胺水平，可为糖尿病确诊及治疗效果的评估提供重要参考。