Mutagenesis in POLH KO and wt RPE1 cell line

We generated POLH knockouts in RPE-1 cell line and treated them with UVA, UVC, and KBrO3 to better understand mutagenesis in xeroderma pigmentosum variant (XP-V) patients. The dataset contains filtered VCF files from the experiments (GRCh37 reference genome). FASTQ raw data is available on NCBI under accession number PRJNA940340.

本研究在RPE-1细胞系中构建了POLH基因敲除细胞模型，并采用UVA、UVC及溴酸钾（KBrO3）对其进行处理，以深入解析着色性干皮病变异型（xeroderma pigmentosum variant, XP-V）患者的诱变机制。本数据集包含本次实验经过滤处理的VCF（Variant Call Format）文件，其参考基因组为GRCh37。FASTQ原始数据可在美国国家生物技术信息中心（NCBI）获取，登录号为PRJNA940340。