Histological characterization of 3-methyl-cholanthrene-induced sarcomas.

1Tumors were classified according to their morphology as spindle, pleomorphic or round cell sarcomas. In some cases, multiple morphologic phenotypes were present in the same tumor.2Local Infiltration was rated as follows: 0 = no tumor infiltration; 1 = minimal tumor infiltration in the surrounding muscle; 2 = massive tumor infiltration.3Necrosis was rated as follows: 0 = no necrosis; 1 = minimal areas of necrosis; 2 = large areas of necrosis.4p53 staining was rated as follows: 0 = no staining; 1 = faint staining in less than 50% of the cells; 2 = strong staining in less than 50% of the cells; 3 = strong staining in more than 50% of the cells. ND = not done.1. 肿瘤依据其形态学特征被分类为梭形细胞肉瘤、多形性肉瘤或圆形细胞肉瘤。部分病例中，同一肿瘤可存在多种形态表型。2. 局部浸润评级标准如下：0级表示无肿瘤浸润；1级表示周围肌肉仅见少量肿瘤浸润；2级表示周围肌肉可见大量肿瘤浸润。3. 坏死评级标准如下：0级表示无坏死；1级表示仅见少量坏死灶；2级表示可见大片坏死灶。4. p53染色评级标准如下：0级表示无染色；1级表示<50%的细胞呈弱阳性染色；2级表示<50%的细胞呈强阳性染色；3级表示>50%的细胞呈强阳性染色。ND表示未检测。