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Neopyrrolomycins with Broad Spectrum Antibacterial Activity

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Neopyrrolomycins_with_Broad_Spectrum_Antibacterial_Activity/2875417
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Three new antibiotics, neopyrrolomycins B (1), C (2), and D (3), with potent activity against Gram-positive pathogens were discovered. They exhibited MIC values < 1 μg/mL versus a number of resistant strains. The compounds were obtained from the ethyl acetate extracts of a Streptomyces sp. after purification by column chromatography and RP-HPLC. Their structures were elucidated using X-ray crystallography (1) and NMR spectroscopy (2 and 3).
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2009-02-27
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