Repair of large traumatic tympanic membrane perforation using ofloxacin otic solution and gelatin sponge

Abstract Introduction Traumatic large tympanic membrane perforations usually fail to heal and require longer healing times. Few studies have compared the healing and hearing outcomes between gelatin sponge patching and ofloxacin otic solution. Objectives To compare the healing outcomes of large traumatic tympanic membrane perforations treated with gelatin sponge, ofloxacin otic solution, and spontaneous healing. Methods Traumatic tympanic membrane perforations >50% of the entire eardrum were randomly divided into three groups: ofloxacin otic solution, gelatin sponge patch and spontaneous healing groups. The healing outcome and hearing gain were compared between the three groups at 6 months. Results A total of 136 patients with large traumatic tympanic membrane perforations were included in analyses. The closure rates were 97.6% (40/41), 87.2% (41/47), and 79.2% (38/48) in the ofloxacin otic solution, gelatin sponge patch, and spontaneous healing groups, respectively (p = 0.041). The mean times to closure were 13.12 ± 4.61, 16.47 ± 6.24, and 49.51 ± 18.22 days in these groups, respectively (p摘要 引言：创伤性大鼓膜穿孔通常难以自行愈合，且愈合周期较长。目前鲜有研究对比明胶海绵贴补疗法与氧氟沙星滴耳液的临床愈合效果及听力预后情况。 目的：对比明胶海绵贴补、氧氟沙星滴耳液治疗与自然愈合三种方案对创伤性大鼓膜穿孔的愈合效果。 方法：将鼓膜穿孔面积占整个鼓膜比例大于50%的创伤性鼓膜穿孔患者随机分为三组：氧氟沙星滴耳液组、明胶海绵贴补组与自然愈合组。于治疗后6个月对比三组患者的愈合效果与听力增益情况。 结果：本研究共纳入136例创伤性大鼓膜穿孔患者进行分析。氧氟沙星滴耳液组、明胶海绵贴补组与自然愈合组的穿孔闭合率分别为97.6%（40/41）、87.2%（41/47）及79.2%（38/48）（P=0.041）。三组患者的平均穿孔闭合时间分别为13.12±4.61天、16.47±6.24天及49.51±18.22天（P