gnomAD Allele Frequency SQLite database V3.1.1

This package scales the huge gnomAD files (on average ~120G/chrom) to a SQLite database with a size of 56G for WGS v3.1.1 (about 760.000.000 variants), and allows scientists to look for minor allele frequencies of variants really fast (A query containing 300.000 variants takes ~40s.) Look here for more information: https://github.com/KalinNonchev/gnomAD_MAF Genomic - variant database gnomAD Allele Frequency SQLite database V3.1.1 for hg38

本工具包可将单条染色体平均大小约120GB的大型gnomAD文件，针对全基因组测序（Whole Genome Sequencing, WGS）v3.1.1版本（涵盖约7.6亿个变异位点）转换为体积仅56GB的SQLite数据库，支持科研人员快速查询变异位点的次要等位基因频率——单次包含30万个变异位点的查询仅需约40秒。更多信息请访问：https://github.com/KalinNonchev/gnomAD_MAF。本数据集属于基因组变异数据库范畴，为适用于hg38参考基因组的gnomAD等位基因频率SQLite数据库v3.1.1。