Identification of miRNAs in Mouse lung epithelial cells (MLE12) expression of which is altered by exposure to cigarette-smoke extracts

Our study aimed to identify miRNAs expression of which is affected by exposure to cigarette smoke (CS) in alveolar type-II cells. Identification and delineation of their modes of action is important for understanding CS-induced failure of repair mechanisms in COPD pathogenesis Cigarette smoke induced changes in miRNAs expression were measured at 2 and 10 hours post-exposure to 10% bubbled through medium cigarette smoke extract