Differential Expression Data from Human CNS Transcriptomics across Alzheimer’s Disease, Lewy Body Diseases, and ALS-FTD

We hypothesized that there is a shared gene expression signature underlying neurodegenerative proteinopathies including Alzheimer’s disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum. To test this hypothesis, we performed a systematic review and meta-analysis of 60 human CNS transcriptomic datasets in the public Gene Expression Omnibus (GEO) and ArrayExpress repositories, comprising a total of 2,600 AD, LBD, and ALS-FTD patients and age-matched controls. Here, we provide the quality control reports and differential expression analyses for each of these 60 datasets. This atlas of differential expression across AD, LBD, and ALS-FTD may guide future work to elucidate the pathophysiological drivers of these individual diseases as well as the common substrate of neurodegeneration.

我们提出如下假说：阿尔茨海默病（Alzheimer’s disease, AD）、路易体病（Lewy body diseases, LBD）以及肌萎缩侧索硬化与额颞痴呆谱系（amyotrophic lateral sclerosis and frontotemporal dementia spectrum, ALS-FTD）等神经退行性蛋白病（neurodegenerative proteinopathies）存在共享的基因表达特征。为验证该假说，我们对公共数据库基因表达综合（Gene Expression Omnibus, GEO）与ArrayExpress中收录的60套人类中枢神经系统（Central Nervous System, CNS）转录组数据集开展了系统综述与荟萃分析，共纳入2600名AD、LBD、ALS-FTD患者及年龄匹配的对照个体。本研究提供了上述60套数据集各自的质量控制报告与差异表达分析结果。这套覆盖AD、LBD与ALS-FTD的差异表达图谱，可为未来阐明这些疾病各自的病理生理驱动因素及神经退行性病变的共同基础提供指导。