Two-locus odds ratios (OR), 95% confidence intervals (95%CI), and p-values for different genotypic combinations of the complement factor H Y402H (genotypes CC/CT/TT) and the LOC387715 A69S (genotypes TT/TG/GG) polymorphisms.

Eight genotype combinations are compared to the non-risk genotype combination TTGG. The risk alleles are C (CFH) and T (LOC387715). All the patients with AMD (n = 332) are compared to the blood donor controls (n = 350). Note the strong correlation between number of risk alleles present in each two-locus genotype and the estimated odd's ratios.本研究将八种基因型组合与非风险基因型组合TTGG进行对比分析。其中风险等位基因为C（CFH）与T（LOC387715）。所有年龄相关性黄斑变性（Age-related Macular Degeneration，AMD）患者（n=332）均与献血者对照人群（n=350）开展组间比较。请注意，双位点基因型中所含风险等位基因的数量与估算所得的比值比（Odds Ratio）之间存在显著相关性。