Supporting data: Modulators of exercise-primed motor skill acquisition

We measured exercise-induced changes in excitation and inhibition using paired-pulse transcranial magnetic stimulation (TMS) in 22 healthy adults, and then had participants learn a novel motor skill — the sequential visual isometric pinch task (SVIPT). We examined the effect of D2 receptor blockade (800 mg sulpiride) on these measures within a randomised, double-blind, placebo-controlled design.

本研究纳入22名健康成人，采用配对脉冲经颅磁刺激（paired-pulse transcranial magnetic stimulation, TMS）检测运动诱发的兴奋与抑制变化，随后让受试者完成一项新型运动技能学习任务——序列视觉等距捏握任务（sequential visual isometric pinch task, SVIPT）。本研究采用随机双盲安慰剂对照设计，探究采用800mg舒必利（sulpiride）实施D2受体阻断（D2 receptor blockade）对上述检测指标的影响。