Data_Sheet_1_Burden of Aortic Aneurysm and Its Attributable Risk Factors from 1990 to 2019: An Analysis of the Global Burden of Disease Study 2019.PDF

BackgroundGlobal and national estimates on the epidemiology of aortic aneurysms are prerequisites for disease management and policymaking. Based on the Global Burden of Disease (GBD) 2019, this study aimed to discern the global aortic aneurysm burden by systematically analyzing demographic data on mortality and exploring the attributable risks and relevant factors.MethodsThe data analyzed in this study were available in the Global Health Data Exchange (GHDx) online query tool. The population in our study comprised individuals from 204 countries and territories from 1990 to 2019. The estimated annual percentage changes (EAPCs) were performed to assess the temporal trends of aortic aneurysms and their attributable risks. Spearman correlation analysis was performed to explore the relationship between the burden of aortic aneurysm and covariates.ResultsAlthough aortic aneurysm-related deaths (82.1%) and disability-adjusted life years (DALYs) (67%) increased from 1990 to 2019, the global trend of age-standardized rate of death (ASRD) (EAPC: −1.34, 95% CI = −1.46 to −1.22, P < 0.001) and age-standardized rate of DALY (ASDALYR) (EAPC: −1.06, 95% CI = −1.17 to −0.95, P < 0.001) decreased, both of which presented age dependence and gender differences. Smoking and high systolic blood pressure (SBP) were the main attributable risks of disease burden and tend to decease globally (EAPC: −1.89, 95% CI = −2.03 to −1.89, P < 0.001; −1.31 95% CI = −1.43 to −1.19, P < 0.001, respectively). Alcohol abstinence (male: R = −0.71, P < 0.001; female: R = −0.73, P < 0.001), smoking age of initiation (male: R = −0.32, P < 0.001; female: R = −0.50, P < 0.001), physical activity (male: R = −0.50, P < 0.001; female: R = −0.55, P < 0.001), and mean temperature (R = −0.62, P < 0.001) had negative correlation with ASRD. However, cholesterol level (male: R = 0.62, P < 0.001; female: R = 0.39, P < 0.001), body mass index (BMI) (male: R = 0.30, P < 0.001; female R = −0.01, P > 0.05), and alcohol consumption (male: R = 0.46, P < 0.001; female: R = 0.42, P < 0.001) had a positive correlation with ASRM. Besides, standard of living and medical resources positively related to burden of aortic aneurysm.ConclusionIn this study, a decreasing trend of aortic aneurysm burden was found globally, especially in advanced regions. Aged men who smoke and women who have hypertension should pay close attention to, particularly in deprived economic groups, and many approaches can be performed to reduce the burden of aortic aneurysms.

背景：全球及各国对主动脉瘤流行病学的估计是疾病管理和政策制定的基础。基于2019年全球疾病负担（GBD）研究，本研究旨在通过系统分析死亡率相关的人口统计数据，探究可归因风险及其相关因素，以揭示全球主动脉瘤的负担。方法：本研究分析的数据来源于全球健康数据交换（GHDx）在线查询工具。研究对象涵盖1990年至2019年间来自204个国家和地区的人群。通过估算年度百分比变化（EAPC）来评估主动脉瘤及其可归因风险的时序趋势。采用Spearman相关性分析以探究主动脉瘤负担与协变量之间的关系。结果：尽管1990年至2019年间与主动脉瘤相关的死亡（82.1%）和伤残调整生命年（DALYs）（67%）有所增加，但全球标准化死亡率（ASRD）（EAPC：-1.34，95% CI = -1.46至-1.22，P < 0.001）和标准化伤残调整生命年率（ASDALYR）（EAPC：-1.06，95% CI = -1.17至-0.95，P < 0.001）均呈下降趋势，且均表现出年龄依赖性和性别差异。吸烟和高血压（SBP）是疾病负担的主要可归因风险，且全球范围内呈下降趋势（EAPC：-1.89，95% CI = -2.03至-1.89，P < 0.001；-1.31，95% CI = -1.43至-1.19，P < 0.001，分别）。戒酒（男性：R = -0.71，P < 0.001；女性：R = -0.73，P < 0.001）、吸烟起始年龄（男性：R = -0.32，P < 0.001；女性：R = -0.50，P < 0.001）、体力活动（男性：R = -0.50，P < 0.001；女性：R = -0.55，P < 0.001）和平均气温（R = -0.62，P < 0.001）与ASRD呈负相关。然而，胆固醇水平（男性：R = 0.62，P < 0.001；女性：R = 0.39，P < 0.001）、体重指数（BMI）（男性：R = 0.30，P < 0.001；女性 R = -0.01，P > 0.05）和酒精摄入量（男性：R = 0.46，P < 0.001；女性：R = 0.42，P < 0.001）与ASRM呈正相关。此外，生活水平与医疗资源与主动脉瘤负担呈正相关。结论：本研究发现，全球主动脉瘤负担呈下降趋势，尤其是在发达地区。吸烟的老年男性及患有高血压的女性应引起特别注意，尤其是在经济条件较差的群体中。针对主动脉瘤负担的降低，可采取多种方法。