Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [RNA-Seq]

To model and characterize the chromatin regulatory landscape of the very first developmental cell fates, we made use of three previously derived and well-characterized Trophoblast Stem Cell (TSCs), Embryonic Stem Cell (ESC) and Extra Embryonic Stem Cell lines (XENs) We performed gene expression profiling in ESC, TSC, XEN and EPISC with RNA-seq technique. Overall design: Characterization of each cell line by RNA-seq analysis and differential analysis among them to identify gene signatures