NormalizedData_wMetaData.xlsx

Normalized unbiased proteomics approach to measure the effect of ETI on inflammatory proteins. Plasma from 20 pediatric pwCF and 20 non-CF (NCF) was collected during routine examinations and 3 months after ETI initiation. Protein screening was performed with an inflammation panel (Target 96, Olink®). Bioinformatics analysis was used to determine changes in protein expression.本研究采用标准化无偏蛋白质组学方法，以检测ETI对炎症蛋白的影响。研究收集了20名儿童囊性纤维化患者（people with cystic fibrosis，pwCF）与20名非囊性纤维化受试者（non-CF，NCF）在常规检查时，以及ETI启动治疗3个月后的血浆样本。采用炎症蛋白检测面板（Target 96，Olink®）完成蛋白质筛选，并通过生物信息学分析确定蛋白表达的变化情况。