Structure of synaptic vesicle protein 2B with padsevonil

Structure of synaptic vesicle protein 2B with padsevonil Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[(4R)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one, 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], ... Authors: Martin, M.F, Mittal, A, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A. Deposit date: 2023-10-19 Release date: 2024-05-22 Last modified: 2024-12-25 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants. Nat.Struct.Mol.Biol., 31, 2024结合帕德塞诺维（padsevonil）的突触囊泡蛋白2B（synaptic vesicle protein 2B）结构。配体描述：(3β,14β,17β,25R)-3-[4-甲氧基-3-(甲氧基甲基)丁氧基]螺甾-5-烯、(4R)-4-(2-氯-2,2-二氟乙基)-1-{[(4R)-2-(甲氧基甲基)-6-(三氟甲基)咪唑并[2,1-b][1,3,4]噻二唑-5-基]甲基}吡咯烷-2-酮、1,2-二癸酰基-SN-甘油-3-磷酸-L-丝氨酸（1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE]）等。作者：Martin, M.F.、Mittal, A.、Levin, E.、Adams, C.、Yang, M.、Ledecq, M.、Horanyi, P.S.、Coleman, J.A. 存档日期：2023-10-19，发布日期：2024-05-22，最后修改日期：2024-12-25。实验方法：电子显微镜（分辨率3.2埃）。引用文献：《结合抗惊厥剂的突触囊泡蛋白2A与2B结构》，*Nat. Struct. Mol. Biol.*，第31卷，2024年。