Contribution of Systemic and Somatic Factors to Clinical Response and Resistance in Urothelial Cancer

Patients with metastatic urothelial cancer (n=29) were treated with atezolizumab (anti-PD-L1). All 29 patients had T-cell receptor sequencing (TCR-seq) of the pre-treatment blood; 24 also had TCR-seq on at least one post-treatment blood sample. 24 patients had TCR-seq of their pre-treatment tumors. TCR-seq data can be found at http://doi.org/10.5281/zenodo.546110. 26 patients also had RNAseq of their tumors and whole exome sequencing (WES) of their tumors and matched normal blood. WES results for one sample were excluded from our analysis after failing to meet coverage requirements.]]>
Inclusion criteria: Patients with locally advanced or metastatic urothelial carcinoma who were treated at Memorial Sloan Kettering Cancer Center (n=29) on protocol NCT02108652. Exclusion criteria: Not providing consent for correlative studies (n=1). ]]>