Knockdown of DKK3 decreases malignant property in head and neck squamous cell carcinoma-derived HSC-3 cells.. Knockdown of DKK3 decreases malignant property in head and neck squamous cell carcinoma-derived HSC-3 cells.

We hypothesized that DKK3 may exert oncogenic function supecifically in head and neck squamous cell carcinoma (HNSCC). DKK3 knockdown in HNSCC cell resulted in decreased cellular proliferation, migration, invasion and in vivo tumor growth. Overall design: Single analysis for each condition (HSC-3 parental cell, HSC-3 shRNA (scramble) and HSC-3 shDKK3 (lentvirus-mediated shRNA targeting to DKK3)