Neutrophil extracellular trap induced dendritic cell activation leads to Th1 polarization in type 1 diabetes

We performed a comparison of transcriptome between monocyte-derived dendritic cells (moDC) cultured with neutrophil extracellular traps (NETs) from healthy donors or type 1 diabetes (T1D) patients. The source of moDCs is healthy donors and T1D patients T1D moDCs were cultivated with healthy NETs, autologous T1D NETs or left untreated. Simularly, healthy moDCs were treated with own healthy NETs, T1D NETs or left untreated