Five loci with a genome-wide significant association to saccular intracranial aneurysm (sIA) disease in the Finnish and Dutch samples.

*For each variant minor allele/major allele, locus and base pair position are given.**The variant's distance (kb) to the nearest gene is given.***Located in the intron of the given gene.†The previously reported 9p21.3 locus [12], [39].‡The previously studied 2q33.3 locus with inconclusive evidence (see Materials and Methods).§Some heterogeneity in effect sizes exists between cohorts. See Table S9 for heterogeneity statistics.*针对每个变异的次要等位基因与主要等位基因，均提供了其所在的基因座（locus）及碱基对位置（base pair position）。 **本研究给出了该变异至最近基因的距离（单位：千碱基，kb）。 ***该变异位于指定基因的内含子区域。 †该位点为此前已有报道的9p21.3基因座[12, 39]。 ‡该位点为此前已被研究但证据尚不明确的2q33.3基因座（详见材料与方法部分）。 §不同队列间的效应量存在一定异质性，相关异质性统计信息详见表S9。