Variation analysis of SARS-CoV-2 complete sequences from Iran: Supplementary data

Aim: SARS-CoV-2 is an emerging coronavirus that was discovered in China and rapidly spread throughout the world. The authors looked at nucleotide and amino acid variations in SARS-CoV-2 genomes, as well as phylogenetic and evolutionary events in viral genomes, in Iran. Materials & methods: All SARS-CoV- 2 sequences that were publicly released between the start of the pandemic and 15 October 2021 were included. Results: Themajority of mutations were found in vaccine target proteins, Spike and Nucleocapsid proteins, and nonstructural proteins. The majority of the viruses that circulated in the early stages of the pandemic belonged to the B.4 lineage. Conclusion: We discovered the prevalence of viral populations in Iran. As a result, tracking the virus’s variation in Iran and comparing it with a variety of nearby neighborhoods may reveal a pattern for future variant introductions.研究目的：严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种新型冠状病毒，最早于中国被发现并迅速在全球范围内传播。本研究针对伊朗境内SARS-CoV-2基因组的核苷酸与氨基酸变异情况，以及病毒基因组的系统发育与进化事件开展分析。 材料与方法：纳入了自新冠疫情大流行起始至2021年10月15日期间公开发布的全部SARS-CoV-2序列数据。 研究结果：绝大多数突变位点分布于疫苗靶标蛋白（刺突蛋白（Spike）、核衣壳蛋白（Nucleocapsid））以及病毒非结构蛋白中。疫情早期在伊朗境内传播的病毒毒株绝大多数属于B.4进化分支。 研究结论：本研究明确了伊朗境内病毒种群的流行特征。综上，对伊朗境内病毒变异情况开展追踪，并与周边多个地区的病毒变异数据进行比对，或可揭示未来病毒变异株传入的潜在规律。