Molecular insights and therapeutic implications of nanoengineered dietary polyphenols for targeting lung carcinoma: part I - Supplementary table

Lung cancer is the second leading cause of cancer-related mortality globally, and non-small-cell lung
cancer accounts for most lung cancer cases. Nanotechnology-based drug-delivery systems have exhibited
immense potential in lung cancer therapy due to their fascinating physicochemical characteristics, in vivo
stability, bioavailability, prolonged and targeted delivery, gastrointestinal absorption and therapeutic
efficiency of their numerous chemotherapeutic agents. However, traditional chemotherapeutics have
systemic toxicity issues; therefore, dietary polyphenols might potentially replace them in lung cancer
treatment. Polyphenol-based targeted nanotherapeutics have demonstrated interaction with a multitude
of protein targets and cellular signaling pathways that affect major cellular processes. This review
summarizes the various molecular mechanisms and targeted therapeutic potentials of nanoengineered
dietary polyphenols in the effective management of lung cancer.