Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135

Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135 Descriptor: 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, Activin receptor type-1, GLYCEROL, ... Authors: Chaikuad, A, Sanvitale, C, Cooper, C, Canning, P, Mahajan, P, Daga, N, Petrie, K, Alfano, I, Gileadi, O, Fedorov, O, Krojer, T, Filippakopoulos, P, Muniz, J.R.C, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) Deposit date: 2012-02-29 Release date: 2012-03-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135 To be Published

与咪唑并[1,2-b]哒嗪类抑制剂K00135结合的ACVR1激酶域晶体结构 描述符：1-(3-{6-[(环丙基甲基)氨基]咪唑并[1,2-b]哒嗪-3-基}苯基)乙酮、激活素受体1型（Activin receptor type-1）、甘油（GLYCEROL）…… 作者：Chaikuad, A、Sanvitale, C、Cooper, C、Canning, P、Mahajan, P、Daga, N、Petrie, K、Alfano, I、Gileadi, O、Fedorov, O、Krojer, T、Filippakopoulos, P、Muniz, J.R.C、von Delft, F、Weigelt, J、Arrowsmith, C.H、Edwards, A.M、Bountra, C、Bullock, A、结构基因组学联合体（Structural Genomics Consortium, SGC） 提交日期：2012-02-29 发布日期：2012-03-21 最后修改日期：2023-09-13 实验方法：X射线衍射（X-RAY DIFFRACTION）（分辨率2.42埃(Å)） 引用信息：与咪唑并[1,2-b]哒嗪类抑制剂K00135结合的ACVR1激酶域晶体结构 待发表